Fig 1: Effects of CD36 on liver SREBP2 activation. A: The mRNA levels of Srebp2 and downstream targets Hmgcr and Ldlr in HFD-fed fl/fl and LKO mice were analyzed by Q-PCR (B). n=8, ∗P < 0.05 vs. fl/fl mice. B: The hepatic expression of SREBP2 and downstream target HMGCR in HFD-fed fl/fl and LKO mice were analyzed by immunoblotting. Quantitation of protein levels was shown in the right. n=3, ∗P < 0.05 vs. fl/fl mice. C: The expression of SREBP2 and downstream target HMGCR in primary hepatocytes from fl/fl and LKO mice were analyzed by immunoblotting. Quantitation of protein levels was shown in the right. n=3, ∗P < 0.05 vs. fl/fl mice. E: The protein levels of SREBP2 of cytoplasmic and nuclear fractions from NC and CD36OE cells were analyzed by immunoblotting.